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Friday, April 17, 2020 | History

5 edition of Tissue-specific estrogen action found in the catalog.

Tissue-specific estrogen action

Tissue-specific estrogen action

novel mechanisms, novel ligands, novel therapies


  • 258 Want to read
  • 14 Currently reading

Published by Springer in Berlin, New York .
Written in English

  • Estrogen -- Receptors -- Congresses.,
  • Estrogen -- Mechanism of action -- Congresses.,
  • Estrogen -- Therapeutic use -- Congresses.

  • Edition Notes

    Includes bibliographical references.

    StatementK.S. KOrach, T. Wintermantel, editors.
    SeriesErnst Schering Foundation symposium proceedings -- 2006/1
    ContributionsKorach, Kenneth S., Wintermantel, Tim.
    LC ClassificationsQP572.E85 T57 2007
    The Physical Object
    Paginationxv, 181 p. :
    Number of Pages181
    ID Numbers
    Open LibraryOL19968269M
    ISBN 103540495479
    ISBN 109783540495475
    LC Control Number2007921596

    "Selective Estrogen Receptor Modulators: Research and Clinical Application is an indispensable resource for evaluating the use of SERM potential alternatives to estrogens. The book synthesizes the current understanding of SERM at the levels of molecular mechanisms and clinical applications and provides a precise and balanced view of ongoing.   TIBOLONE Tibolone is a synthetic steroid with weak estrogenic, progestogenic and androgenic effects. It is advocated for use in a post menopausal women who has not had her period for one year. Due to its tissue specific action, tibolone can be used for relief of vasomotor symptoms, vaginal dryness and prevention of osteoporosis. “The identification of tissue-specific actions of estrogen and direct targets of estrogen receptors will facilitate the development of novel selective ligands that prevent Type 2 diabetes. What organ secrets Antidiuretic Hormone? What is the target and stimulus? What organ secrets Oxytocin? What is the target and stimulus? You just studied 32 terms! Now up your study game with Learn mode. What organ secrets Antidiuretic Hormone? What is the target and stimulus? What organ secrets Oxytocin? What is the target and stimulus?

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Tissue-specific estrogen action Download PDF EPUB FB2

Tissue-Specific Estrogen Action Novel Mechanisms, Novel Ligands, Novel Therapies. Editors: Korach, Kenneth S, Wintermantel, Tim (Eds.) Free Preview. Tissue-Specific Estrogen Action. Ernst Schering Foundation Symposium Proceedings (Book /1) Share your thoughts Complete your review.

Tell readers what you thought by rating and reviewing this book. Rate it * You Rated it *Brand: Springer Berlin Heidelberg. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research. Keywords Cardiovascular Biology Endocrinology Molecular Medicine Pharmacology Steroids cell biology cells endothelium estrogen.

Tissue-Specific Estrogen Action. por. Ernst Schering Foundation Symposium Proceedings (Book /1) ¡Gracias por compartir. Has enviado la siguiente calificación y reseña. Lo publicaremos en nuestro sitio después de haberla : Springer Berlin Heidelberg. Get this from a library. Tissue-specific estrogen action: novel mechanisms, novel ligands, novel therapies ; [Symposium Entitled.

Get this from a library. Tissue-specific estrogen action: novel mechanisms, novel ligands, novel therapies. [Kenneth S Korach; Tim Wintermantel;] -- Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research.

Ten years ago, a review on nuclear receptors was. The model of tissue-specific estrogen action The recent results in steroid hormone research are useful to understand the concept of tissue selectivity. It has been demonstrated that the estrogen receptor is a highly regulated molecule whose transcriptional activity Cited by:   Murphy E., Korach K.S.

() Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues. In: Korach K.S., Wintermantel T. (eds) Tissue-Specific Estrogen Action. Ernst Schering Foundation Symposium Proceedings, vol / by: 6.

Tissue-Specific Regulation of Genes by Estrogen Receptors Article Literature Review in Seminars in Reproductive Medicine 30(1) January with 21 Reads How we measure 'reads'. However, the direct target genes of estrogen and ERs remain largely unknown, as are the mechanisms of E2 action.

In the future, a tissue-specific E2 or SERM might be an appropriate basis for the development of therapeutic regimens for by:   Discover Book Depository's huge selection of Kenneth S Korach books online.

Free delivery worldwide on over 20 million titles. Tissue-Specific Estrogen Action: Novel Mechanisms, Novel Ligands, Novel Therapies. Kenneth S Korach. 10 Jan Undefined. unavailable. The combination of conjugated estrogens and bazedoxifene is approved for women who suffer from moderate-to-severe hot flashes associated with menopause and also to prevent osteoporosis after menopause.

The medicine combines estrogen with bazedoxifene, an estrogen agonist/antagonist (also called a SERM). In women who were between 1 and 5 years post-menopause, use of this. Tissue-bound estrogen in aging. and its indirect action by preventing prolactin from stimulating the formation of estrogen receptors, there are many other processes that can increase or decrease the tissue concentration of estrogen, and many of these influences change with aging.

Tissue specific effects of progesterone on progesterone. It has tissue specific action and acts as an estrogen receptor blocker in breast tissue and exhibits agonistic properties in the bone and uterus. 9 Although its use is primarily in women, in men’s health it is used off-label and acts as an estrogen antagonist in the hypothalamus and pituitary gland.

23 Because of its mechanism of action. Tissue-specific estrogenic response and molecular mechanism Article Literature Review in Toxicology Letters () March with Reads How we measure 'reads'Author: Patrick Diel. The Tissue Specific Role of Estrogen and Progesterone in Human Endometrium and Mammary Gland.

By Karin Tamm, Marina Suhorutshenko, Miia Rõõm, Jaak Simm and Madis Metsis. Submitted: February 1st Reviewed: July 18th Published: January 11th DOI: /Cited by: 1.

Estrogen metabolism. Estrogen synthesis takes place primarily in the ovary (especially membrana granulose and luteinized granulosa cells) in premenopausal women and primarily in peripheral tissues in postmenopausal women [12, 22, 30].The aromatization of androgens into estrogens is the most important source of estrogens in the breast tissue [].Some active estrogens are also formed from Cited by:   Phytoestrogens are markedly similar in chemical structure to the mammalian estrogen, estradiol, and bind to ERs, with a preference for ERβ.

Selective ER modulators (SERMs) are ER ligands that in some tissues act like estrogens, but block estrogen action in others thus exerting tissue‐specific effects through selective : Divya Lakshmanan Mangalath, Chittalakkottu Sadasivan. Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

A characteristic that distinguishes these substances from pure ER agonists and antagonists (that is, full agonists and silent antagonists) is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in ATC code: L02BB.

The tissue-specific estrogen effect reflects the modulation of enzymatic activity in the tissues, specifically breast and uterus. This is shown schematically in Fig. which indicates that tibolone and its metabolites in the breast actually alter the sulfokinase, sulfatase, and hydroxysteroid dehydrogenase enzyme activities in breast Author: David F.

Archer, John Christopher G. Gallagher. tissues. This goal led to the development of selective estrogen-receptor modulators (SERMs) (Levenson and Jordan, ). The SERMs act as tissue-specific estrogen-receptor agonists in the bone, brain, cardiovascular system, vagina, and urogenital system and as estrogen-receptor antagonists in the breast.

Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ERa and ERß. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific : Vijay Paramanik.

The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA).

A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women.

In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density Cited by: 6. Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology to dissect the mechanisms of estrogen-regulated gene expression in target cells, from in vivo analyses using genetic models deficient in estrogen signaling and from synthetic estrogen receptor ligands with isoform- or pathway Cited by: Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30).

Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its receptors, and estradiol synthesis-related enzymes are closely related to Cited by: 4.

Start studying Bio Chapter 13 HW. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen (estradiol)-estrogen receptor complex.

A second estrogen receptor also has been identified, and. Their action is mediated by interaction with classical estrogen receptors (ERs), ERα and ERβ, as well as the more recently identified G-protein coupled receptor 30/G-protein estrogen receptor 1 (GPER1), via both genomic and non-genomic mechanisms.

Estrogens exert a variety of effects in both reproductive and non-reproductive tissues. With the discovery of ERα splice variants, prior assumptions concerning tissue-specific estrogen signaling need to be re-evaluated. Accordingly, we sought to determine the expression of the classical estrogen receptors and ERα splice variants across reproductive and non-reproductive tissues of male and.

Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen -estrogen receptor complex.

A second estrogen receptor also has been identified, and existence of. Serum E2 thresholds establishing sufficiency of estrogen action in various tissues have been proposed.

Clearly however, given the importance of E2 in male health, further studies, using increasingly available mass spectrometry assays, are needed to define the utility of serum E2 measurements in clinical practice. Tamoxifen, sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.

It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer. Serious side effects include a small increased risk of Pregnancy category: AU: B3, US: D (Evidence of risk).

There are no generally accepted, validated methods to screen for or monitor exposure to chemicals that could cause adverse hormonal activity—largely because of the complexity of the endocrine system. Assays and end points for testing and monitoring have been proposed (Gray et al.

; OECD Liang YQ, Akishita M, Kim S, Ako J, Hashimoto M, Iijima K, Ohike Y, Watanabe T, Sudoh N, Toba K, Yoshizumi M, Ouchi Y. Estrogen receptor beta is involved in the anorectic action of estrogen.

Int J Obes Relat Metab Disord ;–9. Roy EJ, Wade GN. Role of food intake in estradiol-induced body weight changes in female rats. A number of available treatments provide relief of menopausal symptoms and prevention of postmenopausal osteoporosis.

However, as breast safety is a major concern, new options are needed, particularly agents with an improved mammary safety profile. Results from several large randomized and observational studies have shown an association between hormone therapy, particularly combined Cited by: 7.

J Steroid Biochem Jan;32(1A) Tissue specific ef-fects of progesterone on progesterone and estrogen receptors in the female urogenital tract. Batra S, Iosif CS. The effect of pro-gesterone administration on progesterone and estrogen receptors in the uterus, vagina and urethra of. Raloxifene (Evista) has the ability to bind to and activate the estrogen receptor while exhibiting tissue-specific effects distinct from estradiol.9 As a result, raloxifene is the first of a Cited by: The mechanisms of action of thyroid hormone (TH), characterized by multiple physiological activities, proposed over the last 80 years are a reflection of the progression of our knowledge about eukaryotic signalling processes.

The cumulative knowledge gained raises the question as to what is so special about the action of this hormone. The discovery in the s that TH receptors belong to the Cited by: Estrogen mimetics, however, do not fall into distinct categories of agonists and antagonists, since their action is regulated by tissue-specific expression of a number Cited by:   Elucidating the mechanism whereby estrogens and SERMs produce tissue-specific effects is important for designing better drugs to treat conditions associated with estrogen deficiency, such as menopausal symptoms and osteoporosis or excessive estrogen action, such as breast cancer.

There is growing evidence that the action of some of these prenylated isoflavonoids is tissue-specific, suggesting that they act like selective estrogen receptor modulators (SERMs), such as the well-known chemically synthesized raloxifene and tamoxifen.The first Specific Aim shall be to define the dose-time interactions of high LET radiation (vs.

low LET radiation) and estradiol to better understand the mechanism of estrogen action. The RBE for cataractogenesis in estrogen-treated animals exposed to1 GeV iron beams shall be determined using Co gamma rays as a standard.This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease.

The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the.